• Biological timekeeping in polar environments: lessons from terrestrial vertebrates 

      Hazlerigg, David Grey; Mizumo Tomotani, Barbara; West, Alexander Christopher; Appenroth, Daniel; Wood, Shona Hiedi (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-30)
      The polar regions receive less solar energy than anywhere else on Earth, with the greatest year-round variation in daily light exposure; this produces highly seasonal environments, with short summers and long, cold winters. Polar environments are also characterised by a reduced daily amplitude of solar illumination. This is obvious around the solstices, when the Sun remains continuously above (polar ...
    • Diversified regulation of circadian clock gene expression following whole genome duplication 

      West, Alexander Christopher; Iversen, Marianne; Jørgensen, Even Hjalmar; Sandve, Simen Rød; Hazlerigg, David; Wood, Shona Hiedi (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-08)
      Across taxa, circadian control of physiology and behavior arises from cell-autonomous oscillations in gene expression, governed by a networks of so-called ‘clock genes’, collectively forming transcription-translation feedback loops. In modern vertebrates, these networks contain multiple copies of clock gene family members, which arose through whole genome duplication (WGD) events during evolutionary ...
    • Evidence for circadian-based photoperiodic timekeeping in Svalbard ptarmigan, the northernmost resident bird 

      Appenroth, Daniel; Wagner, Gabriela; Hazlerigg, David; West, Alexander Christopher (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-29)
      The high Arctic archipelago of Svalbard (74°–81° north) experiences extended periods of uninterrupted daylight in summer and uninterrupted night in winter, apparently relaxing the major driver for the evolution of circadian rhythmicity. Svalbard ptarmigan (<i>Lagopus muta hyperborea</i>) is the only year-round resident terrestrial bird species endemic to the high Arctic and is remarkably adapted to ...
    • Immunologic Profiling of the Atlantic Salmon Gill by Single Nuclei Transcriptomics 

      West, Alexander Christopher; Mizoro, Yasutaka; Wood, Shona; Ince, Louise M.; Iversen, Marianne; Jørgensen, Even Hjalmar; Nome, Torfinn; Sandve, Simen Rød; Martin, Samuel A. M.; Loudon, Andrew S. I.; Hazlerigg, David (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-04)
      Anadromous salmonids begin life adapted to the freshwater environments of their natal streams before a developmental transition, known as smoltification, transforms them into marine-adapted fish. In the wild, smoltification is a photoperiod-regulated process, involving radical remodeling of gill function to cope with the profound osmotic and immunological challenges of seawater (SW) migration. While ...
    • Photoperiod-dependent developmental reprogramming of the transcriptional response to seawater entry in Atlantic salmon (Salmo salar) 

      Iversen, Marianne; Mulugeta, Teshome Dagne; West, Alexander Christopher; Jørgensen, Even Hjalmar; Martin, Samuel A. M.; Sandve, Simen Rød; Hazlerigg, David (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-12)
      The developmental transition of juvenile salmon from a freshwater resident morph (parr) to a seawater (SW) migratory morph (smolt), known as smoltification, entails a reorganization of gill function to cope with the altered water environment. Recently, we used RNAseq to characterize the breadth of transcriptional change which takes place in the gill in the FW phase of smoltification. This highlighted ...
    • Photoperiodic induction without light-mediated circadian entrainment in a High Arctic resident bird 

      Appenroth, Daniel; Melum, Vebjørn Jacobsen; West, Alexander Christopher; Dardente, Hugues; Hazlerigg, David; Wagner, Gabriela (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-21)
      Organisms use changes in photoperiod to anticipate and exploit favourable conditions in a seasonal environment. While species living at temperate latitudes receive day length information as a year-round input, species living in the Arctic may spend as much as two-thirds of the year without experiencing dawn or dusk. This suggests that specialised mechanisms may be required to maintain seasonal ...
    • RNA profiling identifies novel, photoperiodhistory dependent markers associated with enhanced saltwater performance in juvenile Atlantic salmon 

      Iversen, Marianne; Mulugeta, Teshome Dagne; Blikeng, Børge Gellein; West, Alexander Christopher; Jørgensen, Even Hjalmar; Sandve, Simen Rød; Hazlerigg, David (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-08)
      Atlantic salmon migrate to sea following completion of a developmental process known as smolting, which establishes a seawater (SW) tolerant phenotype. Smolting is stimulated by exposure to long photoperiod or continuous light (LL) following a period of exposure to short photoperiod (SP), and this leads to major changes in gill ion exchange and osmoregulatory function. Here, we performed an RNAseq ...